Toggle Main Menu Toggle Search

Open Access padlockePrints

Sex hormone-binding globulin and androgen levels in immigrant and British-born premenopausal British Pakistani women: Evidence of early life influences?

Lookup NU author(s): Professor Nigel Unwin, Dr Colin Fischbacher, Jazz Chamley

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

In women, raised insulin levels are associated with low sex hormone-binding globulin (SHBG) and high androgen levels, which are in turn linked to infertility. Since insulin resistance and hyperinsulinemia are major health problems for South Asians living in Western countries, we predicted that British Pakistani women would have low SHBG and raised androgen levels compared to European women. Given low birth weights in Pakistan, and known links between low birth weight and insulin resistance in later life, we also predicted that immigrant women born in Pakistan would have lower levels of SHBG and higher levels of androgens than British-born British Pakistani women. We assessed SHBG, testosterone, and the free androgen index (FAI) from a single serum sample taken on days 9-11 of the menstrual cycle from 20-40-year-old women living in the UK: 30 immigrants from Pakistan, 30 British-born British Pakistani women, and 25 British-born women of European origin. Age-adjusted analyses showed no significant differences in SHBG, testosterone, or FAI between British-born Pakistani and European-origin women. However, immigrant British Pakistani women had a significantly higher FAI than British-born British Pakistani women. Adjustment for body mass index, waist-to-hip ratio, and smoking status did not affect these results, but further adjustment for height, a marker of early environment, reduced the P-value for the difference in FAI between immigrant and British-born British Pakistani women to below significance. It is possible that the poorer early environment of immigrant British Pakistani women was at least partially responsible for their relatively high levels of free androgens. © 2006 Wiley-Liss, Inc.


Publication metadata

Author(s): Pollard TM, Unwin NC, Fischbacher CM, Chamley JK

Publication type: Article

Publication status: Published

Journal: American Journal of Human Biology

Year: 2006

Volume: 18

Issue: 6

Pages: 741-747

ISSN (print): 1042-0533

ISSN (electronic): 1520-6300

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/ajhb.20526

DOI: 10.1002/ajhb.20526

PubMed id: 17039471


Altmetrics

Altmetrics provided by Altmetric


Share