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Predicting oral drug absorption and hepatobiliary clearance: Human intestinal and hepatic in vitro cell models

Lookup NU author(s): Richard Fearn, Emeritus Professor Barry Hirst

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Abstract

Membrane transport proteins control the uptake and efflux of many drugs in tissues including the intestine, liver and kidneys and thus play important roles in drug absorption, distribution and excretion. With the development of high throughput screening in an industrial environment, the importance of having appropriate in vitro systems to study drug transporter function, regulation, and interactions are invaluable. Cell lines are efficient tools in screening individual transport processes. In this review, we focus on the processes involved in the absorption and hepatobiliary clearance of drugs and the potential of cell lines to model such process, paying particular attention to the use of Caco-2 and HepG2 cells. © 2005 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Fearn RA, Hirst BH

Publication type: Article

Publication status: Published

Journal: Environmental Toxicology and Pharmacology

Year: 2006

Volume: 21

Issue: 2

Pages: 168-178

ISSN (print): 1382-6689

ISSN (electronic): 1872-7077

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.etap.2005.06.002

DOI: 10.1016/j.etap.2005.06.002

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