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Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: A pilot study

Lookup NU author(s): Professor Philip Preshaw, Paula Grainger, Dr Anita Nolan

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Abstract

Background: Recurrent oral aphthous ulceration (ROAU) is a common problem that can result in considerable pain and distress for patients. The aim of this pilot study was to evaluate the role of subantimicrobial dose doxycycline (SDD - 20 mg doxycycline twice daily) in the management of patients with ROAU. Methods: 50 patients with ROAU were randomly allocated to treatment with SDD or placebo for 90 days. Daily ulcer diaries were completed by the participants to record the number of new ulcers and the pain associated with the ulcers. Results: There were significantly more days with no new ulcers in the SDD group (80.4 ± 5.9) than the placebo group (69.8 ± 18.7; P = 0.04). Strong trends were observed towards fewer new ulcers per day, fewer new ulcers over the 90-day period, and more days with no pain in the SDD group compared with the placebo group (P = 0.06-0.08). Conclusion: SDD shows promise as potential therapy in the management of ROAU, though this needs to be confirmed in further studies. © 2007 Blackwell Munksgaard.

Publication metadata

Author(s): Preshaw PM, Grainger P, Bradshaw MH, Mohammad AR, Powala CV, Nolan A

Publication type: Article

Publication status: Published

Journal: Journal of Oral Pathology and Medicine

Year: 2007

Volume: 36

Issue: 4

Pages: 236-240

ISSN (print): 0904-2512

ISSN (electronic): 1600-0714

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1600-0714.2007.00507.x

DOI: 10.1111/j.1600-0714.2007.00507.x

PubMed id: 17391302

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