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Generation of a floxed allele of the mouse endoglin gene

Lookup NU author(s): Kathleen Allinson, Professor Helen Arthur

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Abstract

Endoglin is an auxiliary receptor for TGFβ signalling. Heterozygous germline Endoglin mutations have been identified in patients with the vascular abnormality, Hereditary Haemorrhagic Telangiectasia. Endoglin is upregulated in endothelial cells during angiogenesis and loss of Endoglin in the mouse results in embryonic lethality at mid-gestation. This phenotype points to an important role of Endoglin in new blood vessel formation but precludes analysis at later stages in development and in postnatal life. To bypass this limitation and allow further investigations of the function of Endoglin we have generated a floxed Endoglin allele in which loxP sites flank exons 5 and 6. Mice homozygous for this allele are normal and in the presence of appropriate Cre lines will allow time and cell specific Endoglin deletion for in vivo analysis of function in cardiovascular development and disease. © 2007 Wiley-Liss, Inc.


Publication metadata

Author(s): Allinson KR, Carvalho RLC, Van Den Brink S, Mummery CL, Arthur HM

Publication type: Article

Publication status: Published

Journal: Genesis: The Journal of Genetics and Development

Year: 2007

Volume: 45

Issue: 6

Pages: 391-395

Print publication date: 01/06/2007

ISSN (print): 1526-954X

ISSN (electronic): 1526-968X

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/dvg.20284

DOI: 10.1002/dvg.20284

PubMed id: 17506087


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