Toggle Main Menu Toggle Search

ePrints

Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome

Lookup NU author(s): Phil Botha, Dr Rachel Anderson, Dr James Lordan, Professor John Dark, Professor Paul Corris, Katherine Gould, Professor Andrew Fisher

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Long-term survival after lung transplantation remains limited by the development of bronchiolitis obliterans syndrome (BOS). Allograft colonization with Pseudomonas aeruginosa is common particularly in recipients with BOS, but a possible etiological relationship remains unexplored. In 155 consecutive lung transplants, the development of allograft colonization with Pseudomonas was strongly associated with the development of BOS within 2 years of transplant (23.4% vs. 7.7% in those colonized and not colonized, respectively, P=0.006). Freedom from BOS was significantly shorter in those patients without any pretransplant bacterial reservoir developing de novo allograft pseudomonal colonization as compared with those remaining free of colonization (Kaplan-Meier log-rank P=0.014). The isolation of Pseudomonas preceded the diagnosis of BOS in 14 of 18 (78%) and by a median of 204 days (95% confidence interval 115-492) in patients developing both these complications. We conclude that de novo colonization of the lung allograft by Pseudomonas is strongly associated with the subsequent development of BOS. © 2008 Lippincott Williams & Wilkins, Inc.


Publication metadata

Author(s): Botha P, Archer L, Anderson RL, Lordan JL, Dark JH, Corris PA, Gould KA, Fisher AJ

Publication type: Article

Publication status: Published

Journal: Transplantation

Year: 2008

Volume: 85

Issue: 5

Pages: 771-774

ISSN (print): 0041-1337

ISSN (electronic): 1534-0608

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/TP.0b013e31816651de

DOI: 10.1097/TP.0b013e31816651de

PubMed id: 18337673


Altmetrics

Altmetrics provided by Altmetric


Actions

    Link to this publication


Share