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N-methyl-D-aspartate receptor blockade during development induces short-term but not long-term changes in c-Jun and parvalbumin expression in the rat cervical spinal cord

Lookup NU author(s): Dr Gavin Clowry

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Abstract

During postnatal development, N-methyl-D-aspartate receptor (NMDA-R) expression progressively decreases in ventral and deep dorsal horns. This transient expression might play a role in activity-dependent development of segmental circuitry. NWMA-Rs were blocked unilaterally in the lower cervical spinal cord using Elvax implants that released the NMDA-R antagonist MK-801 maximally over a 2-week period from postnatal day 7 (P7) onward. At P14, the ratio of c-Jun immunoreactive motoneurons ipsilateral/contralateral to the implants was significantly increased and the ratio of parvalbumin immunoreactive neurons decreased, compared to control implants. However, at P84, MK-801-treated and control spinal cords appeared the same. Therefore, NMDA-R blockade during development only transiently altered expression of activity-dependent proteins in the spinal cord, unlike lesions to the developing motor cortex, which we have previously shown to have a permanent effect. (C) 2001 Academic Press.


Publication metadata

Author(s): Gibson CL, Clowry GJ

Publication type: Article

Publication status: Published

Journal: Experimental Neurology

Year: 2000

Volume: 170

Issue: 2

Pages: 380-384

ISSN (print): 0014-4886

ISSN (electronic): 1090-2430

Publisher: Academic Press

URL: http://dx.doi.org/10.1006/exnr.2001.7720

DOI: 10.1006/exnr.2001.7720


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