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Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis, and X-ray cocrystal structure

Lookup NU author(s): Dr Christopher Calabrese, Professor Nicola Curtin, Suzanne Kyle, Huw Thomas, Lan Wang, Professor Alan Calvert, Professor Bernard Golding, Professor Roger Griffin, Professor Herbie Newell


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Author(s): Koch SSC, Thoresen LH, Tikhe JG, Maegley KA, Almassy RJ, Li JK, Yu XH, Zook SE, Kumpf RA, Zhang C, Boritzki TJ, Mansour RN, Zhang KE, Ekker A, Calabrese CR, Curtin NJ, Kyle S, Thomas HD, Wang LZ, Calvert AH, Golding BT, Griffin RJ, Newell DR, Webber SE, Hostomsky Z

Publication type: Article

Journal: Journal of Medicinal Chemistry

Year: 2002

Volume: 45

Issue: 23

Pages: 4961-4974

ISSN (print): 0022-2623

ISSN (electronic): 1520-4804


DOI: 10.1021/jm020259n


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