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Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma

Lookup NU author(s): Dr Amelia Lake, Dr Penelope Taylor

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Abstract

A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.

Publication metadata

Author(s): Cordano P, Lake A, Shield L, Taylor GM, Alexander FE, Taylor PRA, White J, Jarrett RF

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2005

Volume: 128

Issue: 4

Pages: 493-495

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2141.2004.05353.x

DOI: 10.1111/j.1365-2141.2004.05353.x

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