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Transient expression of calcitonin gene-related peptide immunoreactivity in the ventral horn of the post-natal rat cervical spinal cord

Lookup NU author(s): Dr Gavin Clowry

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Abstract

In addition to the well known expression of calcitonin gene-related peptide (CGRP) immunoreactivity in primary afferent fibers in the dorsal horn and in motoneurons, this study has demonstrated, in rat, transient CGRP immunoreactivity in fine caliber varicose axons throughout the ventral horn and in a group of neuron cell bodies in the medial ventral horn. This was first observed at post-natal day 7 (P7) and had disappeared by P21. Physiological studies in chick embryonic spinal cord have shown that CGRP modulates spontaneous activity during development . Neural activity increases post-natally in rat where it may play a role in refinement of sensorimotor synapses. This activity may also be modulated by CGRP. (C) 1999 Elsevier Science B.V. All rights reserved.


Publication metadata

Author(s): Gibson CL, Clowry GJ

Publication type: Article

Publication status: Published

Journal: Developmental Brain Research

Year: 1999

Volume: 115

Issue: 1

Pages: 93-96

Print publication date: 09/06/1999

ISSN (print): 0165-3806

ISSN (electronic): 1872-6755

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/S0165-3806(99)00056-5

DOI: 10.1016/S0165-3806(99)00056-5


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